Rebecca Brown, National Institute of Diabetes and Digestive and Kidney DiseasesBrown works in the Diabetes, Endocrinology, and Obesity Branch of the National Institute of Diabetes and Digestive and Kidney Diseases. Her laboratory studies extreme insulin resistance as well as the role of leptin, the 'satiety hormone', on metabolism and weight gain. By studying rare diseases of insulin and leptin regulation, Brown hopes to provide insights and ultimately treatments for common conditions such as obesity and the metabolic syndrome.
Christian Hinrichs, National Cancer InstituteHinrichs works in the Experimental Transplantation and Immunology Branch of the Center for Cancer Research in the National Cancer Institute. He researches immunotherapy for HPV+ cancers including cervical, oropharyngeal, anal, vulvar, vaginal, and penile malignancies. Hinrichs's laboratory has discovered personalized T cell and gene therapies for HPV+ cancers. As a Lasker Scholar, he will be developing these treatments in clinical trials, investigating why they work in some patients and not in others, and working to discover additional new treatments.
Beth Kozel, National Heart, Lung, and Blood InstituteKozel is a geneticist and a matrix and vascular biologist at the National Heart, Lung, and Blood Institute. She seeks to better understand the factors that influence vascular disease severity in patients with rare connective tissue disorders. The majority of her work is focused on the study of two elastin insufficiency-related diseases: Williams syndrome, a neurodevelopmental condition, and isolated supravalvular aortic stenosis.
Armin Raznahan, National Institute of Mental HealthRaznahan leads the Developmental Neurogenomics Unit in the Child Psychiatry Branch of the National Institute of Mental Health. He combines neuroimaging and genomic and systems-biology approaches to map human brain development and genetically defined disorders that increase risk for neuropsychiatric impairment. This work aims to identify sets of genes and brain systems that can account for the emergence of a shared behavioral syndrome (e.g. autism) across distinct genetic disorders.
Natalie Shaw, National Institute of Environmental Health SciencesShaw conducts research in the Clinical Research Branch at the National Institute of Environmental Health Sciences and is also an adjunct faculty member at the University of North Carolina at Chapel Hill School of Medicine. She is interested in the environmental and genetic control of pubertal development and, specifically, in the effect of sleep disruption and obesity on reproductive hormone secretion. As a Lasker Scholar, Shaw will focus on the genetics behind the timing of pubertal development in adolescent girls.