Small RNAs (~20-30 nucleotides in length) are found in many eukaryotes and act to guard against unwanted RNA such as viruses, transposons and mRNAs. One family of small RNAs called microRNAs regulates protein-coding mRNAs by repressing translation or inducing mRNA decay. Narry Kim discusses how microRNAs play a key role in animal development and diseases such as cancer and gives a step-by-step description of the microRNA biogenesis pathway and the points at which the pathway can be regulated.
Part One: microRNA biogenesis and regulation
Part Two: Tailing in the regulation of microRNA and beyond
In Korean: Overview of microRNA biogenesis and regulation