1993 Albert Lasker Public Service Award

Research, policy, and advocacy for Huntington’s disease

Dr. Wexler has played a pivotal role in recent progress toward a cure for Huntington's disease. Learning that her family was affected by the disease, she did not bemoan her situation, but rose to the challenge and used her adversity to set her life goal to conquering this late-onset, invariably fatal genetic disorder. Through her work with the Hereditary Disease Foundation, she has mobilized the American public to the importance of genetic diseases.

Working in Venezuela, Dr. Wexler and her colleagues constructed an enormous pedigree of over 13,000 individuals, collecting blood samples from more than 3000 people with Huntington's disease in their families. These samples led to the discovery of the Huntington's disease gene at the tip of human chromosome 4 and the recent identification of the gene itself.

Localization of the gene marked the first time that recombinant DNA markers were used successfully to identify a gene whose chromosomal assignment was unknown. The availability of markers tightly linked to the gene led to the development of a presymptomatic test for Huntington's disease. Dr. Wexler directed one of the world's first research programs on genetic counseling and delivery of this test.

Not only has she brought her formidable scientific talents to bear, but her personal charisma has marshaled an army of scientists, citizens and clinicians to work together to attack this genetic disease, and in so doing has provided an example to people working on analogous disorders in other fields.

Dr. Wexler serves as President of the Hereditary Disease Foundation, where she guides its unique workshop program designed to educate scientists and catalyze research on the key biological questions posed by Huntington's disease and other hereditary disorders. The Hereditary Disease Foundation, founded by Dr. Milton Wexler, has been a major vehicle for stimulating interest in Huntington's disease and allied disorders in the scientific community and bringing them to the attention of the public.

To Dr. Nancy Wexler, for her extraordinary research that led to the localization and later identification of the Huntington's disease gene and for mobilizing research, policy development and scientific advocacy in the worldwide effort to find a cure, this 1993 Albert Lasker Public Service Award is given.