Albert Lasker
Basic Medical Research Award

Key Publications of Arthur Horwich
Cheng, M.Y., Hartl, F.U., Martin, J., Pollock, R.A., Kalousek, F., Neupert, W., Hallberg, E.M., Hallberg, R.L. and Horwich, A.L. (1989). Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature. 337, 620-625.

Ostermann, J., Horwich, A.L., Neupert, W. and Hartl, F.U. (1989). Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature. 341, 125-130.

Braig, K., Otwinowski, Z., Hegde, R., Boisvert, D.C., Joachimiak, A., Horwich, A.L. and Sigler, P.B. (1994). The crystal structure of the bacterial chaperonin GroEL at 2.8 A. Nature. 371, 578-86.

Fenton, W.A., Kashi, Y., Furtak, K. and Horwich, A.L. (1994). Residues in chaperonin GroEL required for polypeptide binding and release. Nature. 371, 614-619.

Rye, H.S., Burston, S.G., Fenton, W.A., Beechem, J.M., Xu, Z., Sigler, P.B. and Horwich, A.L. (1997). Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL. Nature. 388, 792-798.

Horwich, A.L., and Fenton, W.A. (2009). Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding. Q. Rev. Biophys. 42, 83-116.