Albert Lasker
Basic Medical Research Award

Key Publications of Franz-Ulrich Hartl
Cheng, M.Y., Hartl, F.U., Martin, J., Pollock, R.A., Kalousek, F., Neupert, W., Hallberg, E.M., Hallberg, R.L. and Horwich, A.L. (1989). Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature. 337, 620-625.

Ostermann, J., Horwich, A.L., Neupert, W. and Hartl, F.U. (1989). Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature. 341, 125-130.

Langer, T., Lu, C., Echols, H., Flanagan, J., Hayer, M.K. and Hartl, F.U. (1992). Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding. Nature. 356, 683-689.

Langer, T., Pfeifer, G., Martin, J., Baumeister, W., and Hartl, F.U. (1992). Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity. EMBO Journal. 11, 4757-4765.

Frydman, J., Nimmesgern, E., Ohtsuka, K. and Hartl, F.U. (1994). Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones. Nature. 370, 111-117.

Hartl, F.U., Bracher, A., and Hayer-Hartl, M. (2011). Molecular chaperones in protein folding and proteostasis. Nature. 475, 324-332.