Lasker~DeBakey
Clinical Medical Research Award

Key Publications of Nicholas Lydon
Buchdunger, E., Zimmermann, J., Mett, H., Meyer, T., Müller, M., Druker, B.J., and Lydon, N.B. (1996). Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56,100-104.

Druker, B.J,, Tamura, S., Buchdunger, E., Ohno, S., Segal, G.M., Fanning, S., Zimmermann, J., and Lydon, N.B. (1996). Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells. Nature Med. 2, 561-566.

Zimmermann, J., Buchdunger, E., Mett, H., Meyer, T., and Lydon, N.B. (1997). Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives. Bioog. Med. Chem. Lett. 7, 187-192.

Gambacorti-Passerini, C., le Coutre, P., Mologni, L., Fanelli, M., Bertazzoli, C., Marchesi, E., Di Nicola, M., Biondi, A., Corneo, G.M., Belotti, D., Pogliani, E., and Lydon, N.B. (1997). Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood Cells Mol. Dis. 23, 380-394.

Druker, B.J., Talpaz, M., Resta, D.J., Peng, B., Buchdunger, E., Ford, J.M., Lydon, N.B., Kantarjian, H., Capdeville, R., Ohno-Jones, S. and Sawyers, C.L. (2001). Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037.

Lydon, N.B., and Druker, B.J. (2004). Lessons learned from the development of imatinib. Leuk. Res. 28S1, S29-S38.