Albert Lasker
Basic Medical Research Award

Key Publications of Gary Ruvkun
Ruvkun, G., and Giusto, J. (1989). The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal switch during development. Nature 338, 313-319.

Wightman, B., Bürglin, T.R., Gatto, J., Arasu, P., and Ruvkun, G. (1991). Negative regulatory sequences in the lin-14 3' untranslated region are necessary to generate a temporal switch during C. elegans development. Genes and Dev. 5, 1813-1824.

Wightman, B., Ha, I., and Ruvkun, G. (1993). Post-transcriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862.

Reinhart, B.J., Slack, F.A., Basson, M., Pasquinelli, A.B., Bettinger, J.C., Rougvie, A.C., Horvitz, H.R., and Ruvkun, G. (2000). The 21 nucleotide let-7 RNA regulates C. elegans developmental timing. Nature 403, 901-906.

Pasquinelli, A., Reinhart, B., Slack, F., Maller, B., Kurodo, M., Martindale, M., Srinivasan, A., Fishman, M., Hayward, D., Ball, E., Degnan, B., M�ller, P., Spring, J., Finnerty, J., Corbo, J., Levine, M., Leahy, P., Davidson, E., and Ruvkun, G., (2000). Conservation across animal phlylogeny of the sequence and temporal expression of the 21 nucleotide let-7 heterochronic regulatory RNA. Nature 408, 86-89.

Ruvkun, G., Wightman, B., and Ha, I. (2004). The 20 years it took to recognize the importance of tiny RNAs. Cell S116, S93-S96.