Albert Lasker
Basic Medical Research Award

Smithies, O. (1955) Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J. 61: 629–641.

Smithies, O., Connell, G.E. and Dixon, G.H. (1962) Chromosomal rearrangements and the evolution of haptoglobin genes. Nature 196: 232–236.

Slightom, J.L., Blechl, A.E., and Smithies, O. (1980) Human Fetal Gy- and Ay-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell 21: 627–638.

Smithies, O., Gregg, R.G., Boggs, S.S., Koralewski, M.A., and Kucherlapati, R.S. (1985) Insertion of DNA sequences into the human chromosomal B-globin locus by homologous recombination. Nature 317: 230–234.

Doetschman, T., Gregg, R.G., Maeda, N., Hooper, M.L., Melton, D.W., Thompson, S., and Smithies, O. (1987) Targeted correction of a mutant hprt gene in mouse embryonic stem cells. Nature 330: 576–578.

Smithies, O., Kim, H.-S., Takahashi, N., and Edgell, M.H. On the importance of quantitative genetic variations in the etiology of hypertension. Kidney International (in press, 2000).