Albert Lasker
Basic Medical Research Award

Key Publications of Martin Evans

Galactosidase messenger in Escherichia coli lysates, J.G. Edwards, D.R. James, A.P. Mathias, and M.J. Evans, Biochem J., 106: p. 32-33, (1967).

The synthesis of rapidly labelled RNA in beta-Galactosidase constitutive mutant of Escherichia coli, J.G. Edwards, D.R. James, A.P. Mathias, and M.J. Evans, Biochim. Biophys. Acta, 213: p. 469-477, (1970).

The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratocarcinoma cells, M.J. Evans, J. Embryol. Exp. Morphol., 28: p. 163-196, (1972).

The morphology and growth of a pluripotent teratocarcinoma cell line and its derivatives in tissue culture, G.R. Martin and M.J. Evans, Cell, 2: p. 163-172, (1974).

The differentiation of clonal teratocarcinoma cell culture in vitro, M.J. Evans and G.R. Martin, in Roche Symposium on Teratomas and Differentiation, D. Solter and M. Sherman, Editors. (1975), Acad. Press NY.

The formation of embryoid bodies in vitro by homogenous embryonal carcinoma cell cultures derived from isolated single cells, M.J. Evans and G.R. Martin, in Roche Symposium on Teratomas and Differentiation, D. Solter and M. Sherman, Editors. (1975), Acad. Press, NY.

Studies with teratoma cells in vitro, M.J. Evans, in The early development of mammals British Society for Developmental Biology, 2nd Symposium, M. Balls and A.E. Wild, Editors. (1975), Cambridge University Press.

A light and electron microscopical study of the nervous tissue of mouse teratomas, R.L. Tresman and M.J. Evans, J. Neurocytol., 4: p. 301-314, (1975).

Cell surface antigens of clonal teratocarcinoma cells at various stages of differentiation, P.L. Stern, G.R. Martin, and M.J. Evans, Cell, 6: p. 455-465, (1975).

The fate of teratocarcinoma cells injected into early mouse embryos, V.E. Papaioannou, M. McBurney, R.L. Gardner, and M.J. Evans, Nature, 258: p. 70-73, (1975).

Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro, G.R. Martin and M.J. Evans, Proc. Natl. Acad. Sci., 72: p. 1441-1445, (1975).

Multiple differentiation of clonal teratoma stem cells following embryoid body formation in vitro, G.R. Martin and M.J. Evans, Cell, 6: p. 467-474, (1975).

Biochemical markers of the progress of differentiation in cloned teratocarcinoma cell lines, E.D. Adamson, M.J. Evans, and G.G. Magrane, Eur. J. Biochem., 7: p. 607, (1977).

Participation of cultured teratocarcinoma cells in mouse embryogenesis, V.E. Papaioannou, R.J. Gardner, M.W. McBurney, C. Babinet, and M.J, Evans, J. Embryol. Exp. Morph., 44: p. 92-104, (1978).

Cell lineages of the mouse and embryonal carcinoma cells:Forssman antigen distribution and patterns of protein synthesis, M.J. Evans, R.H. Lovell-Badge, P.L. Stern, and M.G. Stinnakre, in INSERM Symposium 10, N.L. Douarin, Editor. (1979), Elsevier. p. 115-129.

Changes in protein synthesis during differentiation of embryonal carcinoma cells and a comparison with embryo cells, R.H. Lovell-Badge and M.J. Evans. J. Embryol. Exp. Morph., 59: p. 187-206, (1980).

Origin of mouse embryonal carcinoma cells and the possibility of their direct isolation into tissue culture, M.J. Evans, J. Reprod. Fert., 62: p. 625-631, (1981).

Expression of Forssman antigen in the post-implantation mouse embryo, M.G. Stinnakre, M.J. Evans, K.R. Willison, and P.L. Stern, J. Embryol. Exp. Morph., 61: p. 117-131, (1981).

Stage-specific embryonic antigen involves 1-3 fucosylkated type 2 blood group chains, H.C. Gooi, T. Feizi, A. Kapadia, B.B. Knowles, D. Solter, and M.J. Evans, Nature, 292: p. 156-158, (1981).

Changes in the expression and polarisation of blood group I and i antigens in post implantation embryos and teratocarcinomas of mouse associated with cell differentiation, Kapadia, T. Feizi, and M.J. Evans, Expl. Cell. Res., 131: p. 185-195, (1981).

Are teratocarcinomas formed from normal cells?, M.J. Evans, in Germ Cell Tumours, C.J. Anderson, W.G. Jones, and A. Milford-Ward, Editors. (1981), Taylor and Francis.

Isolation and culture of pluripotential cells from early mouse embryos, M.J. Evans and M.H. Kaufman, J. Anat, 33: p. 107-108, (1981).

Establishment in culture of pluripotential cells from mouse embryos, M.J. Evans and M.H. Kaufman, Nature, 292: p. 154-156, (1981).

Human monoclonal autoantibodies detect changes in expression and polarisation of the I, i antigens during cell differentiation in early mouse embryos and teratocarcinomas, T. Feizi, A. Kapadia, H.C. Gooi, and M.J. Evans, in Teratocarcinoma and Embryonic Cell Interactions, T. Muramatsou, et al., Editors. (1982), Japan Scientific Societies Press and Academic Press: Tokyo.

Isolation properties and karyotype analysis of pluripotent (EK) cell lines from normal and parthenogenetic embryos, E.J. Robertson, M.H. Kaufman, A. Bradley, and M.J. Evans, in Cell Proliferation, Silver and Martin, Editors. (1983): Cold Spring Harbor.

X-chromosome instability in pluripotential stem cell lines derived from parthenogenetic embryos. E.J. Robertson, M.J. Evans, and M.J. Kaufman. J. Embryol. Exp. Morph., 74: p. 297-309, (1983).

The relationship between embryonal carcinoma cells and embryos, M.J. Evans, E.J. Robertson, A. Bradley, and M.H. Kaufman, in 7th Symposium of the British Society for Developmental Biology, "Current Problems in Germ Cell Differentiation," A. McLaren and C.C. Wylie, Editors. (1983), Cambridge University Press.

Pluripotential cells grown directly from normal mouse embryos, M.J. Evans and M.H. Kaufman, in Cancer Surveys, L.M. Franks and R.L. Gardner, Editors. (1983).

Establishment of pluripotential cell lines from haploid mouse embryos. M.H. Kaufman, E.J. Robertson, A.H. Handyside, and M.J. Evans. J. Embryol. Exp. Morph., 73: p. 249-261, (1983).

Experimental Teratomas, M.J. Evans, in Clinics on Oncology, Germ Cell Tumours, Bagshawe, Editor. (1983), Saunders,W.B.: London.

EK cell contribution to chimeric mice: from tissue culture to sperm, M.J. Evans, A. Bradley, and E. Robertson, in Genetic Manipulation of the Early Mammalian Embryo, (1983), Cold Spring Harbor Laboratory: Banbury Report.

A rapid method for analysis of the products of in vitro translation of messenger RNA, D.S. Latchman and M.J. Evans, Analytical Biochem., 131: p. 166-172, (1983).

Approaches to the biochemistry of differentiation of mouse embryonal carcinoma cells, M.J. Evans, R.H. Lovell-Badge, D.S. Latchman, A.J. Stacey, and H. Brzeski, in Gene expression in normal and transformed cells, J.E. Celis, Editor. (1983).

Developmental characteristics of somatic cell hybrids between totipotentent mouse teratocarcinoma and rat intestinal villus cells, A.W.M. Van der Kamp, E.J. Rosa-De Jongh, R.H.J. Houwen, G.G. Margane, J.M. van Dongen, and M.J. Evans, Exp. Cell Res., 154: p. 53-64, (1983).

High-molecular-weight glycoproteins are the major carriers of the carbohydrate differentiation antigens1, i and SSEA-1 of mouse teratocarcinoma cells, R.A. Childs, J. Pennington, K.-I. Uemura, P. Scudder, P.N. Goodfellow, M.J. Evans, and T. Feizi, Biochem J., 215: p. 491-503, (1983).

Influence of injected pluripotential (EK) cells on haploid and diploid parthenogenetic development, M.H. Kaufman, M.J. Evans, E.J. Robertson, and B. A., J. Embryol. Exp. Morph, 80: p. 75-86, (1984).

Expression of the alpha-Fetoprotein gene in pluripotent and committed cells, D.S. Latchman, H. Brzeski, R. Lovell-Badge, and M.J. Evans, Biochima et Biophysica Acta, 783: p. 130-136, (1984).

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines, Bradley, M.J. Evans, M.J. Kaufman, and E.J. Robertson, Nature, 309: p. 255-256, (1984).

A gene sequence expressed only in undifferentiated EC, EK cells and testes, A.J. Stacey and M.J. Evans, EMBO J., 3: p. 2279-2285, (1984).

Transformation of embryonic stem cells with the human type-II collagen gene and its expression in chimeric mice, R.H. Lovell Badge, A.E. Bygrave, A. Bradley, E. Robertson, M.J. Evans, and K.S. Cheah, Cold Spring Harb Symp Quant Biol, 50: p. 707-711 Issn: 0091-7451, (1985).

Protein synthetic patterns of tissues in the early chick embryo, R.H. Lovell-Badge, M.J. Evans, and R. Bellairs, J. Embryol. Exp. Morph., 85: p. 65-80, (1985).

The ability of EK cells to form chimeras after selection of clones in G418 and some observations in the integration of retroviral vector proviral DNA into EK cells, M.J. Evans, A. Bradley, M.R. Kuehn, and E.J. Robertson, in CSH Symposia on Quantitative Biology, (1985).

Germ-line transmission of genes introduced into cultured pluripotential cells by a retroviral vector, E. Robertson, A. Bradley, M. Kuehn, and M.J. Evans, Nature, 323: p. 445-448, (1986).

A potential animal model for Lesch-Nyhan syndrome through introduction of PRT mutations into mice, M.R. Kuehn, A. Bradley, E.J. Robertson, and M.J. Evans, Nature, 326: p. 295-298, (1987).

Transgenic animals and the evaluation of therapeutics, J.D. Coombes and M.J. Evans, Ann. Rep. Med. Chem., 24: p. 207-212, (1989).

Potential for genetic manipulation of mammals, M.J. Evans, Mol. Biol. Med., 6: p. 557-566, (1989).

Maintenance and differentiation in culture of pluripotential embryonic cell lines from pig blastocysts, E. Notarianni, S. Laurie, R.M. Moor, and M.J. Evans, in Genetic Engineering of Animals, W. Hansel and B.J. Weir, Editors. (1990), J. of Reproduction and Fertility. p. 51-56.

PCR Amplification of DNA from replica plated ES cell colonies, G.B. Udy, V.A. Wilson, and M.J. Evans, Technique 2, 2: p. 88-92, (1990).

Maintenance and differentiation in culture of pluripotential embryonic cell lines from pig blastocysts, M.J. Evans, E. Notarianni, and S. Laurie, J. Rep and Fert., 41: p. 51-56, (1990).

Derivation and preliminary characterisation of pluripotent cell lines from porcine and bovine blastocysts, M.J. Evans, E. Notarianni, S. Laurie, and R.M. Moor, Theriogenology, 33: p. 125-128, (1990).

Embryonic Stem Cells as a route to an experimental mammalian genetics. M.J. Evans, Genome Analysis, 2: p. 1-12, (1991).

The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo, F. Poirier, C.T. Chan, P.M. Timmons, E.J. Robertson, M.J. Evans, and P.W. Rigby, Development, 113(4): p. 1105-1114, (1991).

In situ freezing of embryonic stem cells in multiwell plates, S.Y. Chan and M.J. Evans, Trends Genet, 7(3): p. 76, (1991).

Expression of v-src induces aberrant development and twinning in chimaeric mice, C.A. Boulter, A. Aguzzi, R.L. Williams, E.F. Wagner, M.J. Evans, and R. Beddington, Development, 111(2): p. 357-366, (1991).

Derivation of pluripotent, embryonic cell lines from the pig and sheep, E. Notarianni, C. Galli, S. Laurie, R.M. Moor, and M.J. Evans, J Reprod Fertil Suppl, 43: p. 255-260, (1991).

A chimaeric mouse model for autosomal-dominant polycystic kidney disease. C.A. Boulter, A. Aguzzi, M.J. Evans, and N. Affara, Contrib Nephrol, 97: p. 60-70, (1992).

Transgenesis and Genetic Engineering in Domestic Animals, E. Notarianni and M.J. Evans, in Transgenesis, J.A.H. Murray, Editor. (1992), John Wiley & Sons. p. 251-281.

Cystic fibrosis mouse with intestinal obstruction [letter], W.H. Colledge, R. Ratcliff, D. Foster, R. Williamson, and M.J. Evans, Lancet, 340(8820): p. 680, (1992).

Disruption of the cystic fibrosis transmembrane conductance regulator gene in embryonic stem cells by gene targeting, R. Ratcliff, M.J. Evans, J. Doran, B.J. Wainwright, R. Williamson, and W.H. Colledge, Transgenic Res, 1(4): p. 177-181, (1992).

Effects of multiple retrovirus insertions on quantitative traits of mice, P.D. Keightley, M.J. Evans, and W.G. Hill, Genetics, 135(4): p. 1099-1106, (1993).

Transgenic animals as models for human disease -- EC Study Group report. R. Lathe, J.J. Mullins, and M.J. Evans_(contribution), Transgenic Research, 2: p. 288-299, (1993).

Simple and efficient production of embryonic stem cell-embryo chimeras by coculture, S.A. Wood, W.S. Pascoe, C. Schmidt, R. Kemler, M.J. Evans, and N.D. Allen, Proc Natl Acad Sci U S A, 90(10): p. 4582-4585, (1993).

Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts, M.A. Valverde, J.A. O'Brien, F.V. Sepulveda, R. Ratcliff, M.J. Evans, and W.H. Colledge, Pflugers Arch, 425(5-6): p. 434-438, (1993).

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy, S.C. Hyde, D.R. Gill, C.F. Higgins, A.E. Trezise, L.J. MacVinish, A.W. Cuthbert, R. Ratcliff, M.J. Evans, and W.H. Colledge, Nature, 362(6417): p. 250-255, (1993).

Production of a severe cystic fibrosis mutation in mice by gene targeting. R. Ratcliff, M.J. Evans, A.W. Cuthbert, L.J. MacVinish, D. Foster, J.R. Anderson, and W.H. Colledge, Nat Genet, 4(1): p. 35-41, (1993).

The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development, A.J. Warren, W.H. Colledge, M.B. Carlton, M.J. Evans, A.J. Smith, and T.H. Rabbitts, Cell, 78(1): p. 45-57, (1994).

Kinin-stimulated chloride secretion in mouse colon requires the participation of CFTR chloride channels, A.W. Cuthbert, M.J. Evans, W.H. Colledge, L.J. MacVinish, and R. Ratcliff, Br. J. Med. Biol. Res., 27: p. 1-6, (1994).

Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis, A.W. Cuthbert, L.J. MacVinish, M.E. Hickman, R. Ratcliff, W.H. Colledge, and M.J. Evans, Pflugers Arch, 428(5-6): p. 508-515, (1994).

Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice, A.W. Cuthbert, M.E. Hickman, L.J. MacVinish, M.J. Evans, W.H. Colledge, R. Ratcliff, P.W. Seale, and P.P. Humphrey, Br J Pharmacol, 112(1): p. 31-36, (1994).

Microplate DNA preparation, PCR screening and cell freezing for gene targeting in embryonic stem cells, G.B. Udy and M.J. Evans, Biotechniques, 17(5): p. 887-894, (1994).

Tissue culture of embryonic stem cells, M.J. Evans, in Cell Biology: A Laboratory Handbook, J. Celis, Editor. (1994), Academic Press.

Transgenic Rodents, M.J. Evans, D.T. Gilmour, and W.H. Colledge, in Animals with Novel Genes, N. McLean, Editor. (1994), Cambridge University Press: New York.

Transgenic Technologies, M.J. Evans, in The Encyclopedia of Molecular Biology, J. Kendrew and E. Lawrence, Editors. (1994), Blackwell Science: Oxford.

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs, W.H. Colledge, M.B. Carlton, G.B. Udy, and M.J. Evans, Nature, 370(6484): p. 65-68, (1994).

Cystic fibrosis gene therapy, W.H. Colledge and M.J. Evans, in British Medical Bulletin, A.M.L. Lever and P. Goodfellow, Editors. (1995), Churchill Livingstone: London. p. 82-90.

Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice, M.A. Valverde, J.A. O'Brien, F.V. Sepulveda, R.A. Ratcliff, M.J. Evans, and W.H. Colledge, Proc. Natl. Acad. Sci, (1995).

The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine stud, A.W. Cuthbert, J. Halstead, R. Ratcliff, W.H. Colledge, and M.J. Evans, J. Physiol., 482: p. 449-454, (1995).

Initial culture behaviour of rat blastocysts on selected feeder cell lines, N. Ouhibi, N.F. Sullivan, J. English, W.H. Colledge, M.J. Evans, and N.J. Clarke, Mol. Rep. and Dev., 40: p. 311-324, (1995).

Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF mice, J.P. Winpenny, B. Verdon, H. McAlroy, W.H. Colledge, R. Ratcliff, M.J. Evans, M.A. Gray, and B.E. Argent, Pflugers Arch-Eur J. Physiol, 430: p. 26-33, (1995).

Disruption of the adenosine deaminase (ADA) gene using a dicistronic romoterless construct: production of an ADA-deficient homozygote ES cell line, S. Vaulont, S. Daines, and M. Evans, Trans. Res., 4: p. 247-255, (1995).

Gene therapy - future prospects and the consequences, M.J. Evans, N. Affara, and A.M.L. Lever, in British Medical Bulletin, A.M.L. Lever and P. Goodfellow, Editors. (1995), Churchill Livingstone: London. p. 226-234.

Generation and characterization of a DF508 cystic fibrosis mouse model, W.H. Colledge, B.S. Abella, K. Southern, R. Ratcliff, C. Jiang, S.H. Cheng, L.J. MacVinish, J.R. Anderson, A.W. Cuthbert, and M.J. Evans, Nature Genetics, 10: p. 445-452, (1995).

Generation of a pseudogene during retroviral infection, M.B.L. Carlton, W.H. Colledge, and M.J. Evans, Mammalian Genome, 6: p. 90-95, (1995).

The Hox11 gene is essential for cell survival during spleen development, T.N. Dear, W.H. Colledge, M.B. Carlton, I. Lavenir, T. Larson, A.J. Smith, A.J. Warren, M.J. Evans, M.V. Sofroniew, and T.H. Rabbitts, Development, 121(9): p. 2909-2915, (1995).

An indelible lineage marker for Xenopus using a mutated green fluorescent protein, M. Zernicka Goetz, J. Pines, K. Ryan, K.R. Siemering, J. Haseloff, M.J. Evans, and J.B. Gurdon, Development, 122(12): p. 3719-3724, (1996).

The Power of Embryonic Stem Cell Transgenesis for Experimental Mammalian Genetics, M.J. Evans, Endocrinology and Metabolism, 3: p. 45-52, (1996).

CFTR expression and mucin secretion in cultured mouse gallbladder epithelial cells, R.H. Peters, P.J. French, J.H. van Doorninck, G. Lamblin, R. Ratcliff, M.J. Evans, W.H. Colledge, J. Bijman, and B.J. Scholte, Am. J. Physiol, (271): p. 1, (1996).

Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse, M.H. Verlhac, J.Z. Kubiak, M. Weber, G. Geraud, W.H. Colledge, M.J. Evans, and B. Maro, Development, 122(3): p. 815-822, (1996).

Mice lacking tartrate-resistant acid phosphatase (Acp5) have disrupted endochondral ossification and mild osteopetrosis, R. Hayman, S.J. Jones, A. Boyde, D. Foster, W.H. Colledge, M.B. Carlton, M.J. Evans, and T.M. Cox, Development, 122: p. 3151-3162, (1996).

Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2, L.J. MacVinish, D.R. Gill, S.C. Hyde, K.A. Mofford, M.J. Evans, C.F. Higgins, W.H. Colledge, L. Huang, F. Sorgi, R. Ratcliff, and A.W. Cuthbert, J. Physiol, 499: p. 677-687, (1997).

A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca2+-dependent HCO3- secretion, U. Seidler, I. Blumenstein, A. Kretz, D. ViellardBaron, H. Rossmann, W. Colledge, M. Evans, R. Ratcliff, and M. Gregor, Journal of Physiology-London, 505: p. 411-423, (1997).

Complementation of null CF mice with a human CFTR YAC transgene, A.L. Manson, A.E.O. Trezise, L.J. MacVinish, K.D. Kasschau, N. Birchall, V. Episkopou, G. Vassaux, M.J. Evans, W.H. Colledge, A.W. Cuthbert, and C. Huxley, EMBO J., 16: p. 4238 - 4249, (1997).

Gene trapping and functional genomics, M.J. Evans, M.B.L. Carlton, and A.P. Russ, Trends in Genetics, 13: p. 370-374, (1997).

Normotensive blood pressure in mice with a disrupted renin Ren-1d gene, F. Bertaux, W.H. Colledge, S.E. Smith, M. Evans, N.J. Samani, and C.J. Miller, Trans. Res., 6: p. 191-196, (1997).

Normalization of ion transport in murine cystic fibrosis nasal epithelium using gene transfer, L.J. MacVinish, C. Goddard, W.H. Colledge, C.F. Higgins, M.J. Evans, and A.W. Cuthbert, Am. J. of Physiology-Cell Physiology, 273(2): p. 734-740, (1997).

Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice, A.E.O. Trezise, R. Ratcliff, T.E. Hawkins, M.J. Evans, F. T.C., P.R. Romano, C.F. Higgins, and W.H. Colledge, Human Mol. Genetics, 6: p. 527-537, (1997).

Uses of ES cells as vectors to the genome, M.J. Evans, European J. of Cell Biology, 74: p. 51, (1997).

Following cell fate in the living mouse embryo, M. Zernicka Goetz, J. Pines, S. McLean Hunter, J.P. Dixon, K.R. Siemering, J. Haseloff, and M.J. Evans, Development, 124(6): p. 1133-1137, (1997).

Increased contact time improves adenovirus-mediated CFTR gene transfer to nasal epithelium of CF Mice, Jiang, G.Y. Akita, W.H. Colledge, R. Ratcliff, M.J. Evans, K.M. Hehir, J.A. St George, S.C. Wadsworth, and S.H. Cheng, Human Gene Therapy, 8: p. 671-680, (1997).

Cystic fibrosis transmembrane conductance regulator mediates the cyclic adenosine monophosphate-induced fluid secretion but not the inhibition of resorption in mouse gallbladder epithelium, R.H. Peters, J.H. van Doorninck, P.J. French, R. Ratcliff, M.J. Evans, W.H. Colledge, J. Bijman, and B.J. Scholte, Hepatology, (25): p. 270-277, (1997).

The intrinsic Cl- conductance of mouse kidney cortex brush-border membrane vesicles is not related to CFTR, King, W.H. Colledge, R. Ratcliff, and M.J. Evans, Eur. J. Physiol, (434): p. 575-580, (1997).

Whole cell C1- conductances in mouse choroid plexus epithelial cells do not require CFTR expression, J.D. Kibble, C. Garner, W.H. Colledge, m. Brown, H. Kajita, M. Evans, and P.D. Brown, Am. J. Physiol-Cell Physiology, (41): p. 1899-1907, (1997).

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis, D.R. Gill, Southerm K.W., K.A. Mofford, T. Seddon, L. Huang, F. Sorgi, A. Thomson, L.J. MacVinish, R. Ratcliff, D. Bilton, D.L. Lane, J.M. Littlewood, A.K. Webb, P.G. Middleton, W.H. Colledge, A.W. Cuthbert, M.J. Evans, C.F. Higgins, and S.C. Hyde, Gene Therapy, 4: p. 199-218, (1997).

A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea, C.A. Goddard, R. Ratcliff, J.R. Anderson, E. Glenn, S. Brown, D.R. Gill, S.C. Hyde, L.J. MacVinish, L. Huang, C.F. Higgins, A.W. Cuthbert, M.J. Evans, and W.H. Colledge, Gene-Ther, 4(11): p. 1231-1236, (1997).

A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members of the T-box family, S. Wattler, A. Russ, M. Evans, and M. Nehls, Genomics, 48(1): p. 24-33, (1998).

Disruption of murine alpha-enolase by a retroviral gene trap results in early embryonic lethality, Couldrey, M.B.L. Carlton, J. Ferrier, W.H. Colledge, and M.J. Evans, Developmental Dynamics, 212: p. 284-292, (1998).

Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation, F. Wianny, A. Tavares, M.J. Evans, D.M. Glover, and M. Zernicka-Goetz, Chromosoma, 107(6-7): p. 430-439, (1998).

Mutation analysis of the c-mos proto-oncogene in human ovarian teratomas, K.A.F. de Foy, S.A. Gayther, W.H. Colledge, S. Crocket, I.V. Scott, M.J. Evans, and B.A.J. Ponder, Br. J. Cancer, 77: p. 1642-1644, (1998).

Mice deficient for the secreted glycoprotein SPARC/OSTEONECTIN/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens, D.T. Gilmour, G.J. Lyon, M.B.L. Carlton, J.R. Sanes, J.M. Cunningham, J.R. Anderson, B.L.M. Hogan, M.J. Evans, and W.H. Colledge, Embo Journal, 17(7): p. 1860-1870, (1998).

Salmonella typhi uses CFTR for intestinal translocation, providing a basis for the heterozygote advantage in cystic fibrosis, G.B. Pier, M. Grout, T. Zaidi, G. Meluleni, S.S. Mueschenborn, G. Banting, R. Ratcliff, M.J. Evans, and W.H. Colledge, Nature, 393: p. 79-82, (1998).

Thymic lymphomas in mice with a truncating mutation in Brca2, L. Friedman, F. Thistlethwaite, K. Patel, V. Yu, H. Lee, A. Venkitaraman, K. Abel, M., Carlton, S. Hunter, W. Colledge, M. Evans, and B. Ponder, Cancer-Res., 58(7): p. 1338-1343, (1998).

A Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus, M.B.L. Carlton, W.H. Colledge, and M.J. Evans, Developmental Dynamics, 212: p. 242-249, (1998).

Involvement of Brca2 in DNA Repair, K.J. Patel, V.P.C.C. Yu, H. Lee, A. Corcoran, F.C. Thistlethwaite, M.J. Evans, W.H. Colledge, L.S. Friedman, B.A.J. Ponder, and A.R. Venkitaraman, Molecular Cell, 1: p. 347-357, (1998).

Basal chloride currents in murine airway epithelial cells: modulation by CFTR, R. Tarran, M.A. Gray, M.J. Evans, W.H. Colledge, R. Ratcliff, and B.E. Argent, Am. J. Physiol., 274: p. C904-C913, (1998).

Tissue culture of embryonic stem cells, M.J. Evans, Cell Biology: A Laboratory Handbook (Second Edition), 1: p. 86-97, (1998).

Restoration by intratracheal gene transfer of bicarbonate secretion in cystic fibrosis mouse gall bladder, C.M. Curtis, L.C. Martin, C.F. Higgins, W.H. Colledge, M.E. Hickman, M.J. Evans, L.J. MacVinish, and A.W. Cuthbert, Am. J. Physiol., 274: p. G1053-G1060, (1998).

Gene Trapping - A Preface, M.J. Evans, Developmental Dynamics, 212: p. 167-169, (1998).

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2, H. Lee, A. Trainer, L. Friedman, F. Thistlethwaite, M. Evans, B. Ponder, and A. Venkitaraman, Molecular Cell, 4(1): p. 1-10, (1999).

A retroviral gene trap insertion into the histone 3.3A gene causes partial neonatal lethality, stunted growth, neuromuscular deficits and male sub-fertility in transgenic mice, Couldrey, M. Carlton, P. Nolan, W. Colledge, and M. Evans, Human Molecular Genetics, 8(13): p. 2489-2495, (1999).

Non-Surgical Method for the Induction of Delayed Implantation and Recovery of Viable Blastocysts in Rats and Mice by the Use of Tamoxifen and Depo-Provera, S. MacLean Hunter and M. Evans, Molecular Reproduction and Development, 52(1): p. 29-32, (1999).

Polarity of the mouse embryo is anticipated before implantation, R. Weber, R. Pedersen, F. Wianny, M. Evans, and M. Zernicka-Goetz, Development, 126(24): p. 5591-5598, (1999).

Mml, a mouse Mix-like gene expressed in the primitive streak, J.J.H. Pearce and M.J. Evans, Mechanisms of Development, 87: p. 189-192, (1999).

Eomesodermin is required for mouse trophoblast development and mesoderm formation, A.P. Russ, S. Wattler, W.H. Colledge, S.A. Aparicio, M.B. Carlton, J.J. Pearce, S.C. Barton, A.M. Surani, K. Ryan, M.C. Nehls, V. Wilson, and M.J. Evans, Nature, 404: p. 95-99, (2000).

A murine tracheal culture system to investigate parameters affecting gene therapy for cystic fibrosis, E.A. Scott, C.A. Goddard, J.W. Wiseman, M.J. Evans, and W.H. Colledge, Gene Therapy, 7: p. 612-618, (2000).