Albert Lasker
Basic Medical Research Award

Key Publications of Alexander Varshavsky

Finey, D., Ciechanover, A. and Varshavsky, A. (1984) Thermolability of ubiquitin- activating enzyme from the mammalian cell cycle mutant ts85. Cell 37: 43–55.

Ciechanover, A., Finley, D. and Varshavsky, A. (1984) Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell 37: 57–66.

Bachmair, A., Finley, D. and Varshavsky, A. (1986) In vivo half-life of a protein is a function of its N-terminal residue. Science 234: 179–186.

Jentsch, S., McGrath, I. P. and Varshavsky, A. (1987) The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 329: 131–134.

Bachmair, A. and Varshavsky, A. (1989) The degradation signal in a short-lived protein. Cell 56: 1019–1032.

Chliu, V., Tobias, I. W., Bachmair, A., Ecker, D., Gonda, D. K., and Varshavsky, A. (1989) A multiubiquitin chain is confined to a specific lysine in a targeted short-lived protein. Science 243: 1576–1583.

Finley, D., Bartel, B. and Varshavsky, A. (1989) The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature 338: 394–401.

Johnson, E. S., Gonda, D. K. and Varshavsky, A. (1990) Cis-trans recognition and subunit-specific degradation of short-lived proteins. Nature 346: 287–291.

E., Ganoth, D., Armon, T., and Hershko, A. (1989) ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc. Natl. Acad. Sci. USA 86: 7751–7755.