Albert Lasker
Clinical Medical Research Award

Key Publications of David Cushman

Cushman, D.W., Plusec, J., Williams, H.J., Weaver, E.R., Sabo, E.F., Kocy, O., Cheung, H.S., and Ondetti, M.A. (1973) Inhibition of angiotensin-converting enzyme by analogs of peptides from Bothrops jacaraca venom. Experientia 29: 1032–1035.

Ondetti, M.A., Rubin, B., and Cushman, D.W. (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196: 441–444.

Cushman, D.W., Cheung, H.S., Sabo, E.F., Ondetti, M.A. (1978) Design of potent competitive inhibitors of angiotensin-converting enzyme, carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry 16: 5484–5491.

Ondetti, M.A., Condon, M.E., Reid, J., Sabo, E.F. Cheung, H.S., Cushman, D.W. (1979) Design of specific inhibitors of carboxypeptidases. A and B. Biochemistry 18:1427–1430.

Cheung, H.S., Wang, F.L., Ondetti, M.A., Sabo, E.F., and Cushman, D.W. (1980) Binding of peptide substrates and inhibitors of angiotensins-converting enzyme: importance of the carboxyl-terminal dipeptide sequence. J. Biol. Chem. 225: 410–417.

Cushman, D.W. and Ondetti, M.A. History of the design of Captopril and related inhibitors of angiotensin converting enzyme. (1992) Hypertension 17: 589–592.